Allo-Network Drugs: Extension of the Allosteric Drug Concept to Protein- Protein Interaction and Signaling Networks
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چکیده
منابع مشابه
Allo-network drugs: extension of the allosteric drug concept to protein- protein interaction and signaling networks.
Allosteric drugs are usually more specific and have fewer side effects than orthosteric drugs targeting the same protein. Here, we overview the current knowledge on allosteric signal transmission from the network point of view, and show that most intra-protein conformational changes may be dynamically transmitted across protein-protein interaction and signaling networks of the cell. Allo-networ...
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ژورنال
عنوان ژورنال: Current Topics in Medicinal Chemistry
سال: 2013
ISSN: 1568-0266
DOI: 10.2174/1568026611313010007